Cheng Muhlach, her uncle, said the 47-year-old actress was in the hospital since Monday.
Family friend Shirley Kwan who is also the manager of Albert Martinez, Liezl's husband, said in a statement that the actress "peacefully passed away in her sleep."
Liezl is surrounded by her beloved husband, Albert; precious children, Alyanna, Alfonso, and Alyssa; loving mother, Amalia; father Bobby; and her relatives at her time of love and grief.
Martinez was first diagnosed with stage 3 breast cancer in 2007.
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